“And I heard a great voice out of the temple saying to the seven angels, Go your ways, and pour out the vials of the wrath of God upon the earth.” Revelation 16:1
When Christ ceases His intercession in the sanctuary, the unmingled wrath threatened against those who worship the beast and his image and receive his mark will be poured out. “And the third angel followed them, saying with a loud voice, If any man worship the beast and his image, and receive his mark in his forehead, or in his hand, The same shall drink of the wine of the wrath of God, which is poured out without mixture into the cup of his indignation; and he shall be tormented with fire and brimstone in the presence of the holy angels, and in the presence of the Lamb.” Revelation 14:9, 10 The plagues upon Egypt when God was about to deliver Israel were similar in character to those more terrible and extensive judgments which are to fall upon the world just before the final deliverance of God’s people. Says the revelator, in describing those terrific scourges: “There fell a noisome and grievous sore upon the men which had the mark of the beast, and upon them which worshipped his image.” The sea “became as the blood of a dead man: and every living soul died in the sea.” And “the rivers and fountains of waters…became blood.” Terrible as these inflictions are, God’s justice stands fully vindicated. The angel of God declares: “Thou art righteous, O Lord,…because thou hast judged thus. For they have shed the blood of saints and prophets, and thou hast given them blood to drink; for they are worthy.” Revelation 16:2-6 By condemning the people of God to death, they have as truly incurred the guilt of their blood as if it had been shed by their hands…
In the plague that follows, power is given to the sun “to scorch men with fire. And men were scorched with great heat…” Revelation 16:8, 9
These plagues are not universal, or the inhabitants of the earth would be wholly cut off. Yet they will be the most awful scourges that have ever been known to mortals. All the judgments upon men, prior to the close of probation, have been mingled with mercy. The pleading blood of Christ has shielded the sinner from receiving the full measure of his guilt; but in the final judgment, wrath is poured out unmixed with mercy.
The bolts of God’s wrath are soon to fall, and when He shall begin to punish the transgressors, there will be no period of respite until the end. The storm of God’s wrath is gathering, and those only will stand who are sanctified through the truth in the love of God. They shall be hid with Christ in God till the desolation shall be overpast.
E. G. White, Maranatha (The Lord Is Coming) p. 267